| 1 | 1563 | - 1563—1564: London Plague
Bubonic plague epidemic - London, England.
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| 2 | 1592 | - 1592—1596: Seneca nation measles epidemic
Affected an unknow number of Seneca natives in North America
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| 3 | 1603 | - 1603: London plague epidemic
Bubonic plague epidemic in London, England that killed 40,000 people.
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| 4 | 1616 | - 1616—1620: New England infections epidemic
Affected Southern New England, British North America, especially the Wampanoag people, and killed an estimated 30% to 90% of specific populations.
Unknown source, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D
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| 5 | 1633 | - 1633—1634: Massachusetts smallpox epidemic
Made about 1,000 victims
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| 6 | 1634 | - 1634—1640: Wyandot people epidemic of infections
Killed between 15,000 and 25,000 Wyandot people of North America.
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| 7 | 1637 | - 1637—1637: London plague epidemic
Bubonic plague epidemic in London and Westminster, England - Killed about 10,000 people
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| 8 | 1665 | - 1665—1666: Great Plague of London
Bubonic plague. Killed an estimated 100,000 individuals
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| 9 | 1668 | - 1668—1668: France plague
Bubonic plague, killed 20,000 individuals.
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| 10 | 1677 | - 1677—1678: Boston smallpox epidemic
Smallpox epidemic that killed 750 to 1,000 residents of the Massachusetts Bay Colony, British North America
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| 11 | 1693 | - 1693—1693: Boston yellow fever epidemic
Killed 3,000 residents of Boston, Massachussetts.
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| 12 | 1699 | - 1699—1699: Charleston and Philadelphia yellow fever epidemic
Killed 300 in Charleston, 220 in Philadelphia.
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| 13 | 1702 | - 1702—1702: New York City yellow fever epidemic
Killed 500 residents of New York.
- 1702—1703: St. Lawrence Valley smallpox epidemic
Killed 300 settlers of New France along the Saint-Lawrence river valley.
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| 14 | 1713 | - 1713—1715: North America measles epidemic
Killed an unknow number of residents of the Thirteen Colonies and New France, Canada
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| 15 | 1720 | - 1720—1722: Great Plague of Marseille
Bubonic plague - over 100,000 dead in France.
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| 16 | 1852 | - 12 Feb 1852—9 Apr 1870: Napoleon III
Nephew of Napoleon I; elected as President of the French Republic in 1848, made himself Emperor of the French after a coup d'état. Captured by the German army on September 2, 1870; deposed in absentia following the proclamation of the Third Republic.[103]
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| 17 | 1918 | - 1 Mar 1918—1 Apr 1920: Spanish Flu Epidemic
The worldwide Spanish Flu epidemic killed at least 17 million people worldwide.
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