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Date |
Event(s) |
| 1 | 1616 | - 1616—1620: New England infections epidemic
Affected Southern New England, British North America, especially the Wampanoag people, and killed an estimated 30% to 90% of specific populations.
Unknown source, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D
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| 2 | 1633 | - 1633—1634: Massachusetts smallpox epidemic
Made about 1,000 victims
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| 3 | 1634 | - 1634—1640: Wyandot people epidemic of infections
Killed between 15,000 and 25,000 Wyandot people of North America.
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| 4 | 1637 | - 1637—1637: London plague epidemic
Bubonic plague epidemic in London and Westminster, England - Killed about 10,000 people
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