1 | 1634 | - 1634—1640: Wyandot people epidemic of infections
Killed between 15,000 and 25,000 Wyandot people of North America.
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2 | 1665 | - 1665—1666: Great Plague of London
Bubonic plague. Killed an estimated 100,000 individuals
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3 | 1668 | - 1668—1668: France plague
Bubonic plague, killed 20,000 individuals.
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4 | 1677 | - 1677—1678: Boston smallpox epidemic
Smallpox epidemic that killed 750 to 1,000 residents of the Massachusetts Bay Colony, British North America
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