1 | 1665 | - 1665—1666: Great Plague of London
Bubonic plague. Killed an estimated 100,000 individuals
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2 | 1668 | - 1668—1668: France plague
Bubonic plague, killed 20,000 individuals.
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3 | 1677 | - 1677—1678: Boston smallpox epidemic
Smallpox epidemic that killed 750 to 1,000 residents of the Massachusetts Bay Colony, British North America
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4 | 1693 | - 1693—1693: Boston yellow fever epidemic
Killed 3,000 residents of Boston, Massachussetts.
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5 | 1699 | - 1699—1699: Charleston and Philadelphia yellow fever epidemic
Killed 300 in Charleston, 220 in Philadelphia.
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6 | 1702 | - 1702—1702: New York City yellow fever epidemic
Killed 500 residents of New York.
- 1702—1703: St. Lawrence Valley smallpox epidemic
Killed 300 settlers of New France along the Saint-Lawrence river valley.
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7 | 1713 | - 1713—1715: North America measles epidemic
Killed an unknow number of residents of the Thirteen Colonies and New France, Canada
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8 | 1720 | - 1720—1722: Great Plague of Marseille
Bubonic plague - over 100,000 dead in France.
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