1563—1564: London Plague Bubonic plague epidemic - London, England.
2
1592
1592—1596: Seneca nation measles epidemic Affected an unknow number of Seneca natives in North America
3
1603
1603: London plague epidemic Bubonic plague epidemic in London, England that killed 40,000 people.
4
1616
1616—1620: New England infections epidemic Affected Southern New England, British North America, especially the Wampanoag people, and killed an estimated 30% to 90% of specific populations.
Unknown source, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D